Tetracycline derivatives and process for preparing them

ABSTRACT

Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## 
     Methods of making the same; pharmaceutical compositions containing the same.

The present invention relates to tetracycline derivatives and to a process for preparing them.

It is known that tetracyclines can be subjected to a reaction at the 2-carbonamide group with aldehydes and amines to form the corresponding amino-alkyl derivatives. While it is possible to vary the amine component within wide limits, the choice of the carbonyl component is restricted. Thus, for example, ketones are not suitable for this reaction and among the aldehydes only those react well which are particularly reactive, for example formaldehyde.

Now, we have found that water-soluble tetracycline derivatives can be prepared in unexpected easy manner when using aldehydes of the type of glyoxal-monoacetal.

Hence, the present invention provides tetracyclines which are substituted at the amide group and correspond to the general formula I ##SPC2##

in which R¹ and R², which may be identical or different, represent a low molecular alkyl group of 1 to 5 carbon atoms or, together, an ethylene or propylene group, R³ and R⁴, which may be identical or different, represent hydrogen, alkyl of 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, which may be branched and which may be substituted once or several times by identical or different substituents of the series of hydroxyl groups, low molecular dialkylamino groups, low molecular dialkyl-carbamoyl groups, low molecular alkoxy-carbonyl groups, phenyl groups, a heterocyclic radical, in particular a 5- or 6-membered ring which may be interrupted by oxygen and/or nitrogen, or an carboxyl group, and in which latter case the alkyl group may also be substituted additionally by an amino group, or a cycloalkyl group of 5 to 7 carbon atoms, and in which R³ and R⁴ may also be closed to a 5- or 6-membered ring which may be interrupted by a nitrogen or oxygen atom and which may be substituted by low molecular alkyl, low molecular hydroxyalkyl, low molecular carboxyalkyl, hydroxyl or carbonyl, R⁵ and R⁶, which may be identical or different, represent hydrogen or a hydroxy group, R⁷ repreents hydrogen or a methyl group, R⁶ and R⁷ together represent a methylene group, and R⁸ represents hydrogen, chlorine, bromine or a low molecular dialkyl-amino group of 1 to 4 carbon atoms, and their physiologically tolerated salts.

The invention furthermore relates to a process for preparing the above-identified compounds of the general formula I, which comprises reacting a tetracycline of the formula II ##SPC3##

in which the radicals R⁵ to R⁸ have the meanings given above, optionally in the form of its salt, with an aldehyde of the formula III ##STR1## in which R¹ and R² have the meanings given above, and with an amine of the formula IV ##STR2## in which the radicals R³ and R⁴ have the meanings given above.

As compounds of the formula II, there may be used all tetracyclines having an unsubstituted amide group and prepared by fermentation methods or by partial synthesis, for example tetracycline, oxytetracycline, 7-chlorotetracycline, 7-bromo-tetracycline, 6-desmethyl-7-chlorotetracycline, 6-desmethyl-tetracycline, 6-desmethyl-6-desoxy-tetracycline, 6-desoxytetracycline, 6-desoxy-5-oxy-tetracycline, 4-desdimethylamino-5-oxytetracycline, 6-desmethyl-6-desoxy-7-dimethylamino-tetracycline, 6-desmethyl-6-desoxy-7-diethylamino-tetracycline, 6-desmethyl-6-desoxy-6-methylene-tetracycline and 6-desmethyl-6-desoxy-5-hydroxy-6-methylene-tetracycline.

Examples of the glyoxal-monoacetals are, in particular, the dimethyl-, diethyl-, dipropyl-, dibutyl-monoacetal and the cyclic ethylene-glycol monoacetal. The acetal component may be prepared according to the method described in Helv. Chem. Acta 18, 514 (1935).

As amino components of the formula IV to be used according to the invention, there may be mentioned, besides ammonia, for example the following primary or secondary aliphatic or heterocyclic amines: methylamine, ethylamine, n-propylamine, i-propylamine, n-butylamine, i-butylamine, pentylamine, hexylamine, dimethylamine, diethylamine, di-n-butylamine, di-n-hexylamine, cyclopentylamine, cyclohexylamine, cycloheptylamine, diethylamino-ethylamine, bis-(diethylaminoethyl)-amine, ethanolamine, diethanolamine, methylhydroxyethylamine, benzylamine, dibenzylamine, β-phenylethylamine, 2-morpholinoethylamine, 2-piperidinopropylamine, 2-pyrrolidino-ethylamine, dimethylcarbamoyl-ethylamine, glycine, alanine, leucine, threonine, valine, phenylalanine, aspartic acid, glutamic acid, α-aminobutyric acid, lysine, ornithine, arginine, proline, histidine, piperidine, pyrrolidine, piperazine, morpholine, α-methylpyrrolidine, α,β- or α,α-dimethylpyrrolidine, N-methylpiperazine, N-(β-hydroxyethyl)-piperazine and 4-carboxyethylpiperazine.

The process of the invention is carried out, for example, by dissolving or suspending a tetracycline of the formula II or a salt thereof in a suitable solvent, for example a low molecular alcohol such as ethanol, propanol, i-propanol butanol, glycol, or an ether such as glycol monomethyl ether, glycol dimethyl ether, dioxane, tetrahydrofurane, or in tetramethyl-urea, dimethylformamide, hexamethylphosphoric acid triamide, N-methyl-pyrrolidine, or in a low molecular halogenated hydrocarbon, for example chloroform or methylene chloride and allowing it to react at temperatures between about 0° and 100° C, preferably at about 20° to about 50° C. If excess quantities of compounds of the formula III or IV are used, the excess may vary within wide limits, for example between about 1 and about 10 moles. It is sufficient, however, to operate with about an equimolar amount or with a slight excess.

The reaction partners may be dissolved in any desired order or introduced in substance into the solvent. It is of advantage, however, to mix the glyoxalacetal III with the amino component IV in the solvent and then to add the tetracycline in solid form.

After stirring for several hours under an inert gas, for example nitrogen, the reaction time being, as a rule, about three hours when carrying out the reaction at room temperature, the reaction products can be obtained, for example by concentrating the solution under reduced pressure to less than one-third of its original volume of the solution and subsequent addition of a non-polar solvent, for example ether, petroleum ether or cyclohexane, in pure solid form.

The process of the invention may be carried out in one or two stages, for example as transaminoalkylation. For the transaminoalkylation which may be carried out with or without isolation of the aminoalkyl compound, there may be used, for example, aminoalkyl compounds of H-acidic compounds, for example water, alcohols, imides, secondary amines or malonic acid derivatives, which are then reacted with the tetracycline component.

As acids forming physiologically tolerated salts of the compounds of the formula I of the invention, there may be used, for example mineral acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and organic acids such as acetic acid, citric acid, maleic acid, succinic acid and tartaric acid. The organic salt formers themselves may have a pharmaceutical action such as that of, for example, penicillins, cephalosporins, panthothenic acid, chloramphenicol-hemisuccinate, salicylic acid, ascorbic acid or nalidixinoic acid.

The salts of the products of the invention may be prepared, for example, by combining equimolar solutions of the components in polar solvents, for example water, alcohol or dimethylformamide, whereupon the salts may be isolated by precipitation, freeze-drying, evaporation or re-precipitation. In this process, the acid component may be added during or after the reaction of tetracycline, acetal and amine. The salts of the final products may also be obtained by using, according to the invention, the tetracycline or amino component in the form of their salts.

The easy formation of the products of the invention with very high yields is surprising, because this reaction normally proceeds with low yield with other aldehydes, with the exception of formaldehyde. As the reactivity of acetaldehyde in reactions with tetracyclines and amines is considerably reduced in comparison to that of formaldehyde, it was not expected that the use of a substituted and branched acetaldehyde, which has, sterically, less favourable conditons for such a reaction, would lead to a smooth reaction with high yields.

Tetracyclines which are substituted at the 2-carbox-amido group have been used for years successfully in the chemotherapy of bacterial infections.

The compounds of the invention are distinguished by a very good solubility in water and good tolerance, which makes them suitable especially for parenteral administration.

Another advantage of the compounds of the invention is their good stability in solution. Thus, for example, the solutions have a good stability with regard to colour change and clarity.

In addition, the products of the invention have a surprising and unexpected action against S. typhimurium which is stronger than that of tetracyclines.

For their administration, about 1 to 10% solutions, preferably about 2 to 5% aqueous solutions or also aqueous buffer solutions having a pH-value of between about 4 and 9, are used.

The products of the invention may also be used, for example in the form of tablets, dragees or capsules manufactured with the use of the usual adjuvants and excipients, for example starch, talcum, lactose, and so on.

The quantity of active substance in a sngle dose may be in the range of between about 200 and about 1500 mg, preferably between about 250 and about 500 mg.

It is also possible to combine the compounds of the invention with other therapeutic agents, for example penicillins, chloramphenicol, gentamycine or sulfonamides.

Examples of the compounds of the invention of the general formula I ##SPC4##

are, for example, the derivatives of the tetracyclines indicated in Table I, the oxytetracyclines indicated in Table II, the chlorotetracyclines indicated in Table III, the 6-desoxy-oxytetracyclines of Table IV and the 6-desmethyl-7-chlorotetracyclines of Table V, the sections listed under the number A representing the compounds of particular importance. With a view to permit easier survey of the compounds regarding nomenclature, only the substituents R¹ to R⁸ are indicated which, together with the compounds of the general formula I, represent the individual compounds.

                                      Table IA                                     __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR3##       H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR4##       H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR5##       H   OH  CH.sub.3                                                                           H                                     ##STR6##                                                               CH.sub.3                                                                                ##STR7##                    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR8##                    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR9##                H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR10##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR11##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR12##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR13##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR14##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             C.sub. 2 H.sub.5                                                                       n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR15##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR16##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR17##      H   OH  CH.sub.3                                                                           H                                     ##STR18##                                                              C.sub.2 H.sub.5                                                                         ##STR19##                   H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR20##                                                             H       OH                           CH.sub.3                                                                           H                                     C.sub.2 H.sub.5                                                                             ##STR21##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR22##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR23##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR24##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR25##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH CH.sub.3                                                                        H                                 n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR26##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR27##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH H                                                                         OH  CH.sub.3                                                                           3   H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR28##      H   OH  CH.sub.3                                                                           H                                     ##STR29##                                                              n-C.sub.3 H.sub.7                                                                       ##STR30##                   H   OH  CH.sub. 3                                                                          H                             n-C.sub.3 H.sub.7                                                                       ##STR31##                   H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR32##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR33##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR34##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR35##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR36##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR37##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR38##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR39##      H   OH  CH.sub.3                                                                           H                                     ##STR40##                                                              n-C.sub.4 H.sub.9                                                                       ##STR41##                   H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR42##                   H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR43##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 .sub.9                                                                            ##STR44##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR45##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR46##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR47##               H   OH  CH.sub.3                                                                           H                             __________________________________________________________________________

                                      Table IB                                     __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               H            H               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR48##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR49##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR50##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR51##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR52##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR53##                                                                                   ##STR54##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR55##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR56##      H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR57##      H   OH  CH.sub.3                                                                           H                                     ##STR58##                                                              CH.sub.3                                                                                    ##STR59##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR60##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR61##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR62##               H   OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR63##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            H               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub. 2 H.sub.4 OH                                                                            H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR64##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             C.sub. 2 H.sub.5                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR65##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR66##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR67##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR68##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub. 5                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR69##                                                                                   ##STR70##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR71##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR72##      H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR73##      H   OH  CH.sub.3                                                                           H                                     ##STR74##                                                              C.sub.2 H.sub.5                                                                             ##STR75##               H   H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR76##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR77##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR78##               H   OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR79##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            H               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR80##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR81##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR82##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR83##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR84##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                       ##STR85##                                                                                   ##STR86##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub. 7                                                                     CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR87##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR88##      H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR89##      H   OH  CH.sub.3                                                                           H                                     ##STR90##                                                              n-C.sub.3 H.sub.7                                                                           ##STR91##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR92##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR93##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR94##               H   OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR95##               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            H               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.5 H.sub.11                                                                             H   OH CH.sub.3                                                                        H                                 n-C.sub.4 H.sub.9                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR96##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR97##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR98##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR99##      H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR100##     H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR101##                                                                                  ##STR102##     H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR103##     H   OH CH.sub.3                                                                        H                                 n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR104##     H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR105##     H   OH  CH.sub.3                                                                           H                                     ##STR106##                                                             n-C.sub.4 H.sub.9                                                                           ##STR107##              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR108##              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR109##              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR110##              H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR111##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            H               H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub. 2                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR112##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH 2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                   H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2H                                                                       ##STR113##  H               OH  CH.sub.3                                                                           H                                 (CH.sub.2).sub.2                                                                       H                                                                                            ##STR114##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR115##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR116##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                        ##STR117##                                                                                  ##STR118##     H   OH CH.sub.3                                                                        H                                 (CH.sub.2).sub.2                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2C.sub. 6 H.sub.5                                                                    CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR119##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR120##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR121##     H   OH  CH.sub.3                                                                           H                                      ##STR122##                                                            (CH.sub.2).sub.2                                                                            ##STR123##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR124##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR125##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR126##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2 ).sub.2                                                                           ##STR127##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            H               H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.3        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H n-C.sub.3 H.sub.7                                                                         H               OH  CH.sub.3                                                                           H                                 (CH.sub.2).sub.3                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR128##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR129##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR130##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR131##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR132##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2 ).sub.3                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                        ##STR133##                                                                                  ##STR134##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR135##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR136##     H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR137##     H   OH  CH.sub.3                                                                           H                                     ##STR138##                                                             (CH.sub.2).sub.3                                                                            ##STR139##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR140##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR141##              H   OH  CH.sub.3 H                        (CH.sub.2).sub.3                                                                            ##STR142##              H   OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR143##              H   OH  CH.sub.3                                                                           H                             __________________________________________________________________________

                                      TABLE IIA                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOH    OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR144##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR145##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR146##     OH  OH  CH.sub.3                                                                           H                                     ##STR147##                                                             CH.sub.3                                                                                ##STR148##                  OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR149##                  OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR150##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR151##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR152##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR153##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR154##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub. 2 H.sub.5                                                                               OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR155##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR156##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR157##     OH  OH  CH.sub.3                                                                           H                                     ##STR158##                                                             C.sub.2 H.sub.5                                                                         ##STR159##                  OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR160##                  OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR161##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR162##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR163##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR164##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR165##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub. 9                                                                          n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR166##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR167##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR168##     OH  OH  CH.sub.3                                                                           H                                     ##STR169##                                                             n-C.sub.3 H.sub.7                                                                       ##STR170##                  OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                       ##STR171##                  OH  OH  CH.sub.3                                                                           H                             n-C.sub. 3 H.sub.7                                                                          ##STR172##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR173##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR174##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR175##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR176##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR177##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR178##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR179##     OH  OH  CH.sub.3                                                                           H                                     ##STR180##                                                             n-C.sub.4 H.sub.9                                                                       ##STR181##                  OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR182##                  OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR183##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR184##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR185##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR186##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR187##              OH  OH  CH.sub.3                                                                           H                             __________________________________________________________________________

                                      Table IIB                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               H            H               OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR188##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2 CH.sub.2CON(CH.sub.3).sub.2                                                           OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR189##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR190##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR191##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR192##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR193##                                                                                  ##STR194##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub. 2CH.sub.2 OH                                                                   OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR195##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR196##     OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR197##     OH  OH  CH.sub.3                                                                           H                                     ##STR198##                                                             CH.sub.3                                                                                    ##STR199##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR200##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR201##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR202##              OH  OH  CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR203##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            H               OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR204##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2 CH.sub.2CH.sub.2 OH                                                                   OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub. 5                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR205##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR206##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR207##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR208##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR209##                                                                                  ##STR210##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR211##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR212##     OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR213##     OH  OH  CH.sub.3                                                                           H                                     ##STR214##                                                             C.sub.2 H.sub.5                                                                             ##STR215##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR216##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR217##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR218##              OH  OH  CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR219##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            H               OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub. 3 H.sub.7                                                                     H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR220##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub. 2CON(CH.sub.3).sub.2                                                                   OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR221##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR222##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR223##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR224##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub. 11                                                                            OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                       ##STR225##                                                                                  ##STR226##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub. 6 H.sub.5                                                               OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR227##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR228##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR229##     OH  OH  CH.sub.3                                                                           H                                      ##STR230##                                                            n-C.sub.3 H.sub.7                                                                           ##STR231##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR232##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR233##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR234##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR235##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            H               OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub. 9                                                                     H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR236##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 N(C.sub.2 H.sub.5).sub.2                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR237##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR238##     H   OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR239##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR240##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR241##                                                                                  ##STR242##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub. 4 OH                                                                            OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR243##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR244##     OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR245##     OH  OH  CH.sub.3                                                                           H                                     ##STR246##                                                             n-C.sub.4 H.sub.9                                                                           ##STR247##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR248##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR249##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR250##              OH  OH  CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR251##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            H               OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR252##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR253##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR254##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR255##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR256##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                              (CH.sub.2).sub.2                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                        ##STR257##                                                                                  ##STR258##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2 C.sub.6 H.sub.5                                                               OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR259##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR260##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR261##     OH  OH  CH.sub.3                                                                           H                                     ##STR262##                                                             (CH.sub.2).sub.2                                                                            ##STR263##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR264##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR265##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR266##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR267##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            H               OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.3        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.5 OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR268##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR269##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR270##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR271##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR272##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                        ##STR273##                                                                                  ##STR274##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR275##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR276##     OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR277##     OH  OH  CH.sub.3                                                                           H                                     ##STR278##                                                             (CH.sub.2).sub.3                                                                            ##STR279##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR280##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR281##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR282##              OH  OH  CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR283##              OH  OH  CH.sub.3                                                                           H                             __________________________________________________________________________

                                      Table IIIA                                   __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2 COOC.sub.2 H.sub.5                                                                    H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR284##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR285##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR286##     H   OH  CH.sub.3                                                                           Cl                                    ##STR287##                                                             CH.sub.3                                                                                ##STR288##                  H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                ##STR289##                  H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR290##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR291##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR292##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR293##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR294##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            C.sub. 2 H.sub.5                                                                       C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2 COOC.sub.2 H.sub.5                                                                    H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR295##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR296##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR297##     H   OH  CH.sub.3                                                                           Cl                                    ##STR298##                                                             C.sub.2 H.sub.5                                                                         ##STR299##                  H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                         ##STR300##                  H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR301##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR302##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR303##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR304##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR305##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR306##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR307##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR308##     H   OH  CH.sub.3                                                                           Cl                                    ##STR309##                                                             n-C.sub.3 H.sub.7                                                                       ##STR310##                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                       ##STR311##                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR312##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR313##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR314##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR315##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR316##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR317##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR318##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR319##     H   OH  CH.sub.3                                                                           Cl                                    ##STR320##                                                             n-C.sub.4 H.sub.9                                                                       ##STR321##                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                       ##STR322##                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR323##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR324##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR325##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR326##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR327##              H   OH  CH.sub.3                                                                           Cl                            __________________________________________________________________________

                                      TABLE IIIB                                   __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               H            H               H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR328##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR329##     H   OH  CH.sub. 3                                                                          Cl                            CH.sub.3                                                                               H                                                                                            ##STR330##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR331##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR332##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                ##STR333##                                                                                  ##STR334##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub. 3                                                                          Cl                            CH.sub.3                                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR335##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR336##     H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                               H                                                                                            ##STR337##     H   OH  CH.sub.3                                                                           Cl                                    ##STR338##                                                             CH.sub.3                                                                                    ##STR339##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR340##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR341##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR342##              H   OH  CH.sub.3                                                                           Cl                            CH.sub.3                                                                                    ##STR343##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            H               H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR344##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub. 2 OH                                                                   H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                               H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR345##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR346##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR347##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR348##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                         ##STR349##                                                                                  ##STR350##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR351##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR352##     H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR353##     H   OH  CH.sub.3                                                                           Cl                                    ##STR354##                                                             C.sub.2 H.sub.5                                                                             ##STR355##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR356##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR357##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR358##              H   OH  CH.sub.3                                                                           Cl                            C.sub.2 H.sub.5                                                                             ##STR359##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          H                 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.3          H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          C.sub.2 H.sub.5   H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          n-C.sub.3 H.sub.7 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          n-C.sub.4 H.sub.9 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          i-C.sub.3 H.sub.7 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          i-C.sub.4 H.sub.9 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          n-C.sub.5 H.sub.11                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          n-C.sub.6 H.sub.13                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          C.sub.2 H.sub.4 OH                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR360##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2CH.sub.2 OH                                                                      H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                                H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                         H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                         H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2 CON(CH.sub.3).sub.2                                                                     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2C.sub.6 H.sub.5                                                                          H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H          CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR361##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR362##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR363##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR364##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.5 H.sub.11                                                                        n-C.sub.5 H.sub.11                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.6 H.sub.13                                                                        N-C.sub.6 H.sub.13                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      i-C.sub.3 H.sub.7                                                                         i-C.sub.3 H.sub.7 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      i-C.sub.4 H.sub.9                                                                         i-C.sub.4 H.sub.9 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.4 OH                                                                        C.sub.2 H.sub.4 OH                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                       ##STR365##                                                                                ##STR366##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3   C.sub.2 H.sub.4 OH                                                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                      H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2C.sub.6 H.sub.5                                                                   CH.sub.2C.sub.6 H.sub.5                                                                          H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                           CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                  H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR367##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR368##       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                          ##STR369##       H   OH  CH.sub.3                                                                           Cl                                    ##STR370##                                                             n-C.sub.3 H.sub.7                                                                           ##STR371##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR372##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR373##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR374##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.3 H.sub.7                                                                           ##STR375##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            H               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub. 9                                                                     H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR376##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR377##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR378##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR379##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR380##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                       ##STR381##                                                                                  ##STR382##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR383##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR384##     H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR385##     H   OH  CH.sub.3                                                                           Cl                                    ##STR386##                                                             n-C.sub.4 H.sub.9                                                                           ##STR387##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR388##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR389##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR390##              H   OH  CH.sub.3                                                                           Cl                            n-C.sub.4 H.sub.9                                                                           ##STR391##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            H               H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR392##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2 CH.sub.2CON(CH.sub.3).sub.2                                                           H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR393##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR394##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR395##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR396##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub. 3                                                                          Cl                            (CH.sub.2).sub.2                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                        ##STR397##                                                                                  ##STR398##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR399##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR400##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR401##     H   OH  CH.sub.3                                                                           Cl                                    ##STR402##                                                             (CH.sub.2).sub.2                                                                            ##STR403##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                            ##STR404##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                            ##STR405##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                            ##STR406##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.2                                                                            ##STR407##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2 ).sub.3                                                                      H            H               H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.3        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.5 H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR408##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR409##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR410##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR411##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR412##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                        ##STR413##                                                                                  ##STR414##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR415##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2 ).sub.3                                                                      H                                                                                            ##STR416##     H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR417##     H   OH  CH.sub.3                                                                           Cl                                    ##STR418##                                                             (CH.sub.2).sub.3                                                                            ##STR419##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                            ##STR420##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                            ##STR421##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                            ##STR422##              H   OH  CH.sub.3                                                                           Cl                            (CH.sub.2).sub.3                                                                            ##STR423##              H   OH  CH.sub.3                                                                           Cl                            __________________________________________________________________________

                                      Table IVA                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOH    OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR424##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR425##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR426##     OH  H   CH.sub.3                                                                           H                                     ##STR427##                                                             CH.sub.3                                                                                ##STR428##                  OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR429##                  OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR430##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR431##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR432##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR433##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR434##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR435##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR436##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR437##     OH  H   CH.sub.3                                                                           H                                     ##STR438##                                                             C.sub.2 H.sub.5                                                                         ##STR439##                  OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR440##                  OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR441##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR442##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR443##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR444##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR445##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR446##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR447##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR448##     OH  H   CH.sub.3                                                                           H                                     ##STR449##                                                             n-C.sub.3 H.sub.7                                                                       ##STR450##                  OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub. 7                                                                      ##STR451##                  OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR452##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR453##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR454##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR455##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR456##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub. 4 H.sub.9                                                                     H            CH.sub.2COOH    OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR457##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR458##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR459##     OH  H   CH.sub.3                                                                           H                                     ##STR460##                                                             n-C.sub.4 H.sub.9                                                                       ##STR461##                  OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR462##                  OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR463##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR464##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR465##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR466##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR467##              OH  H   CH.sub.3                                                                           H                             __________________________________________________________________________

                                      TABLE IVB                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               H            H               OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR468##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR469##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR470##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR471##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR472##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                ##STR473##                                                                                  ##STR474##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub. 3                                                                          H                             CH.sub.3                                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR475##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR476##     OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                               H                                                                                            ##STR477##     OH  H   CH.sub.3                                                                           H                                     ##STR478##                                                             CH.sub.3                                                                                    ##STR479##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR480##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR481##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR482##              OH  H   CH.sub.3                                                                           H                             CH.sub.3                                                                                    ##STR483##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            H               OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR484##     OH  H   CH.sub.3                                                                           H                             CH.sub.2 H.sub.5                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub. 3                                                                          H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2C.sub. 6 H.sub.5                                                               OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR485##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR486##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR487##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR488##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                         ##STR489##                                                                                  ##STR490##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR491##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR492##     OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR493##     OH  H   CH.sub.3                                                                           H                                     ##STR494##                                                             C.sub.2 H.sub.5                                                                             ##STR495##              OH  H   CH.sub.3                                                                            H                            C.sub.2 H.sub.5                                                                             ##STR496##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR497##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR498##              OH  H   CH.sub.3                                                                           H                             C.sub.2 H.sub.5                                                                             ##STR499##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            H               OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR500##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR501##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR502##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR503##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR504##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                       ##STR505##                                                                                  ##STR506##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR507##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR508##     OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR509##     OH  H   CH.sub.3                                                                           H                                     ##STR510##                                                             n-C.sub.3 H.sub.7                                                                           ##STR511##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR512##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR513##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR514##              OH  H   CH.sub.3                                                                           H                             n-C.sub.3 H.sub.7                                                                           ##STR515##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            H               OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR516##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR517##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR518##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR519##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR520##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                       ##STR521##                                                                                  ##STR522##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR523##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR524##     OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR525##     OH  H   CH.sub.3                                                                           H                                     ##STR526##                                                             n-C.sub.4 H.sub.9                                                                           ##STR527##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR528##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR529##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR530##              OH  H   CH.sub.3                                                                           H                             n-C.sub.4 H.sub.9                                                                           ##STR531##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            H               OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             CH.sub.2).sub.2                                                                        H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub. 2                                                                      H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR532##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR533##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR534##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR535##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR536##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                        ##STR537##                                                                                  ##STR538##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR539##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR540##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                       H                                                                                            ##STR541##     OH  H   CH.sub.3                                                                           H                                     ##STR542##                                                             (CH.sub.2).sub.2                                                                            ##STR543##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR544##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR545##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR546##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.2                                                                            ##STR547##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            H               OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.3        OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.5 OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR548##     OH  H   CH.sub. 3                                                                          H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CON(CH.sub. 3).sub.2                                                           OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR549##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR550##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR551##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR552##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              OH  H   CH.sub.3                          (CH.sub.2).sub.3                                                                       i-C.sub.4 H.sub. 9                                                                          i-C.sub.4 H.sub.9                                                                              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                        ##STR553##                                                                                  ##STR554##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR555##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR556##     OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                       H                                                                                            ##STR557##     OH  H   CH.sub.3                                                                           H                                     ##STR558##                                                             (CH.sub.2).sub.3                                                                            ##STR559##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR560##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR561##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR562##              OH  H   CH.sub.3                                                                           H                             (CH.sub.2).sub.3                                                                            ##STR563##              OH  H   CH.sub.3                                                                           H                             __________________________________________________________________________

                                      TABLE VA                                     __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        H   OH  H   Cl                            CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 H   OH  H   Cl                            CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   Cl                            CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2COOH    H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR564##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR565##     H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR566##     H   OH  H   Cl                                    ##STR567##                                                             CH.sub.3                                                                                ##STR568##                  H   OH  H   Cl                            CH.sub.3                                                                                ##STR569##                  H   OH  H   Cl                            CH.sub.3                                                                                    ##STR570##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR571##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR572##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR573##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR574##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub. 7                                                                          n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR575##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR576##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR577##     H   OH  H   Cl                                    ##STR578##                                                             C.sub.2 H.sub.5                                                                         ##STR579##                  H   OH  H   Cl                            C.sub.2 H.sub.5                                                                         ##STR580##                  H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR581##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR582##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR583##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR584##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR585##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR586##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR587##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR588##     H   OH  H   Cl                                    ##STR589##                                                             n-C.sub.3 H.sub.7                                                                       ##STR590##                  H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                       ##STR591##                  H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR592##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR593##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR594##              H   OH  H   Cl                            n-C.sub.3 H.sub. 7                                                                          ##STR595##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR596##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR597##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR598##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR599##     H   OH  H   Cl                                    ##STR600##                                                             n-C.sub.4 H.sub.9                                                                       ##STR601##                  H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                       ##STR602##                  H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR603##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR604##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR605##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR606##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR607##              H   OH  H   Cl                            __________________________________________________________________________

                                      TABLE VB                                     __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               H            H               H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.3        H   OH  H   Cl                            CH.sub.3                                                                               H            C.sub.2 H.sub.5 H   OH  H   Cl                            CH.sub.3                                                                               H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            CH.sub.3                                                                               H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            CH.sub.3                                                                               H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR608##     H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            CH.sub.3                                                                               H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR609##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR610##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR611##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR612##     H   OH  H   Cl                            CH.sub.3                                                                               n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            CH.sub.3                                                                               n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            CH.sub.3                                                                               i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            CH.sub.3                                                                               C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            CH.sub.3                                                                                ##STR613##                                                                                  ##STR614##     H   OH  H   Cl                            CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            CH.sub.3                                                                               CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            CH.sub.3                                                                               CH.sub.2C.sub.6 H.sub. 5                                                                    CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            CH.sub.3                                                                               CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR615##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR616##     H   OH  H   Cl                            CH.sub.3                                                                               H                                                                                            ##STR617##     H   OH  H   Cl                                    ##STR618##                                                             CH.sub.3                                                                                    ##STR619##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR620##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR621##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR622##              H   OH  H   Cl                            CH.sub.3                                                                                    ##STR623##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            H               H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.3        H   OH  H   Cl                            C.sub. 2 H.sub.5                                                                       H            C.sub.2 H.sub.5 H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR624##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub. 2N(C.sub.4 H.sub.9).sub.2                                                      H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR625##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR626##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR627##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR628##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                         ##STR629##                                                                                  ##STR630##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR631##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR632##     H   OH  H   Cl                            C.sub.2 H.sub.5                                                                        H                                                                                            ##STR633##     H   OH  H   Cl                                    ##STR634##                                                             C.sub.2 H.sub.5                                                                             ##STR635##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR636##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR637##              H   OH  h   Cl                            C.sub.2 H.sub.5                                                                             ##STR638##              H   OH  H   Cl                            C.sub.2 H.sub.5                                                                             ##STR639##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                       H           H               H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.3        H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR640##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H             CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                      H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR641##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR642##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR643##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR644##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                       ##STR645##                                                                                  ##STR646##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR647##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR648##     H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR649##     H   OH  H   Cl                                    ##STR650##                                                             n-C.sub.3 H.sub.7                                                                           ##STR651##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR652##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR653##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR654##              H   OH  H   Cl                            n-C.sub.3 H.sub.7                                                                           ##STR655##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            H               H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.3        H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.5 H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR656##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.                                                       H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR657##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR658##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR659##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR660##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                       ##STR661##                                                                                  ##STR662##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR663##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR664##     H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR665##     H   OH  H   Cl                                    ##STR666##                                                             n-C.sub.4 H.sub.9                                                                           ##STR667##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR668##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR669##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR670##              H   OH  H   Cl                            n-C.sub.4 H.sub.9                                                                           ##STR671##              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            H               H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.3        H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.5 H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR672##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2CON(CH.sub.3).sub.2                                                            H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR673##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR674##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR675##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR676##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                        ##STR677##                                                                                  ##STR678##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2CH.sub.2 OH                                                                 CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR679##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR680##     H   OH  H   Cl                            (CH.sub.2).sub.2                                                                       H                                                                                            ##STR681##     H   OH  H   Cl                                    ##STR682##                                                             (CH.sub.2).sub.2                                                                            ##STR683##              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                            ##STR684##              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                            ##STR685##              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                            ##STR686##              H   OH  H   Cl                            (CH.sub.2).sub.2                                                                            ##STR687##              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            H               H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.3        H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.5 H   OH  H   Cl                            (CH.sub. 2).sub.3                                                                      H            n-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR688##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                                       H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2N(C.sub.4 H.sub.9).sub.2                                                       H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(CH.sub.3).sub.2                                                      H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2CH.sub.2N(C.sub.2 H.sub.5).sub.2                                               H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(CH.sub.3).sub.2                                                                    H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2 CON(CH.sub.3).sub.2                                                           H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CON(C.sub.2 H.sub.5).sub.2                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H            CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                                H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR689##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR690##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR691##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR692##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       n-C.sub.5 H.sub.11                                                                          n-C.sub.5 H.sub.11                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       n-C.sub.6 H.sub.13                                                                          n-C.sub.6 H.sub.13                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       i-C.sub.3 H.sub.7                                                                           i-C.sub.3 H.sub.7                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       i-C.sub.4 H.sub.9                                                                           i-C.sub.4 H.sub.9                                                                              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       C.sub.2 H.sub.4 OH                                                                          C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                        ##STR693##                                                                                  ##STR694##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       CH.sub.3     C.sub.2 H.sub.4 OH                                                                             H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       CH.sub. 2CH.sub.2CH.sub.2 OH                                                                CH.sub.2CH.sub.2CH.sub.2 OH                                                                    H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       CH.sub.2C.sub.6 H.sub.5                                                                     CH.sub.2C.sub.6 H.sub.5                                                                        H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       CH.sub.2CH.sub.2C.sub.6 H.sub.5                                                             CH.sub.2CH.sub.2C.sub.6 .sub.5                                                                 H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR695##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR696##     H   OH  H   Cl                            (CH.sub.2).sub.3                                                                       H                                                                                            ##STR697##     H   OH  H   Cl                                    ##STR698##                                                             (CH.sub.2).sub.3                                                                            ##STR699##              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                            ##STR700##              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                            ##STR701##              H   OH  H   Cl                             (CH.sub.2).sub.3                                                                           ##STR702##              H   OH  H   Cl                            (CH.sub.2).sub.3                                                                            ##STR703##              H   OH  H   Cl                            __________________________________________________________________________

As further Examples are mentioned:

                                      Table VIA                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        H   OH  H   H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 H   OH  H   H                             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   H                             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   H                             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   H                             CH.sub.3                                                                               H            CH.sub.2COOH    H   OH  H   H                             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   H                             CH.sub.3                                                                               H                                                                                            ##STR704##     H   OH  H   H                             CH.sub.3                                                                               H                                                                                            ##STR705##     H   OH  H   H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   H                             CH.sub.3                                                                               H                                                                                            ##STR706##     H   OH  H   H                                     ##STR707##                                                                      ##STR708##                  H   OH  H   H                             CH.sub.3                                                                                ##STR709##                  H   OH  H   H                             CH.sub.3                                                                                    ##STR710##              H   OH  H   H                             CH.sub.3                                                                                    ##STR711##              H   OH  H   H                             CH.sub.3                                                                                    ##STR712##              H   OH  H   H                             CH.sub.3                                                                                    ##STR713##              H   OH  H   H                             CH.sub.3                                                                                    ##STR714##              H   OH  H   H                             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        H   OH  H   H                             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 H   OH  H   H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   H                             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   H                             C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2 COOH   H   OH  H   H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR715##     H   OH  H   H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR716##     H   OH  H   H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR717##     H   OH  H   H                                     ##STR718##                                                             C.sub.2 H.sub.5                                                                         ##STR719##                  H   OH  H   H                             C.sub.2 H.sub.5                                                                         ##STR720##                  H   OH  H   H                             C.sub.2 H.sub.5                                                                             ##STR721##              H   OH  H   H                             C.sub.2 H.sub.5                                                                             ##STR722##              H   OH  H   H                             C.sub.2 H.sub.5                                                                             ##STR723##              H   OH  H   H                             C.sub.2 H.sub.5                                                                             ##STR724##              H   OH  H   H                             C.sub.2 H.sub.5                                                                             ##STR725##              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR726##     H   OH  H   H                             n-C.sub.3 H.sub. 7                                                                     H                                                                                            ##STR727##     H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR728##     H   OH  H   H                                     ##STR729##                                                             n-C.sub.3 H.sub.7                                                                       ##STR730##                  H   OH  H   H                             n-C.sub.3 H.sub.7                                                                       ##STR731##                  H   OH  H   H                             n-C.sub.3 H.sub.7                                                                           ##STR732##              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                           ##STR733##              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                           ##STR734##              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                           ##STR735##              H   OH  H   H                             n-C.sub.3 H.sub.7                                                                           ##STR736##              H   OH  H   H                              n-C.sub.4 H.sub.9                                                                     CH.sub.3     CH.sub.3        H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR737##     H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR738##     H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   OH  H   H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR739##     H   OH  H   H                                     ##STR740##                                                             n-C.sub.4 H.sub.9                                                                       ##STR741##                  H   OH  H   H                             n-C.sub.4 H.sub.9                                                                       ##STR742##                  H   OH  H   H                             n-C.sub.4 H.sub.9                                                                           ##STR743##              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                           ##STR744##              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                           ##STR745##              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                           ##STR746##              H   OH  H   H                             n-C.sub.4 H.sub.9                                                                           ##STR747##              H   OH  H   H                             __________________________________________________________________________

                                      Table VIB                                    __________________________________________________________________________     R.sub.1, R.sub.2                                                                       R.sub.3      R.sub.4         R.sub.5                                                                            R.sub.6                                                                            R.sub.7                                                                            R.sub.8                       __________________________________________________________________________     CH.sub.3                                                                               CH.sub.3     CH.sub.3        H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H            CH.sub.2COOH    H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H                                                                                            ##STR748##     H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H                                                                                            ##STR749##     H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H            H.sub.2CH.sub.2COOH                                                                            H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               H                                                                                            ##STR750##     H   H   H   N(CH.sub.3).sub.2                     ##STR751##                                                             CH.sub.3                                                                                ##STR752##                  H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                                ##STR753##                  H   H   H                                 N(CH.sub.3).sub.2                                                              CH.sub.3                                                                                    ##STR754##              H   H   H   N(CH.sub.3).sub.2              CH.sub.3                                                                                   ##STR755##              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                                    ##STR756##              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                                    ##STR757##              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                                    ##STR758##              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        CH.sub.3     C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR759##     H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR760##     H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOC.sub. 2 H.sub.5                                                            H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR761##     H   H   H   N(CH.sub.3).sub.2                     ##STR762##                                                             C.sub.2 H.sub.5                                                                         ##STR763##                  H   H   H   N(CH.sub.2).sub.2             C.sub.2 H.sub.5                                                                         ##STR764##                  H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                             ##STR765##              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                             ##STR766##              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                             ##STR767##              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                             ##STR768##              H   H   H   N(CH.sub.3).sub.2             C.sub.2 H.sub.5                                                                             ##STR769##              H   H   H   N(CH.sub.3 ).sub.2            n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C2 H.sub.5      H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOH    H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR770##     H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR771##     H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H             CH.sub.2CH.sub.2COOH                                                                          H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR772##     H   H   H   N(CH.sub.3).sub.2                     ##STR773##                                                             n-C.sub.3 H.sub.7                                                                       ##STR774##                  H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                       ##STR775##                  H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                           ##STR776##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                           ##STR777##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.3 H.sub.7                                                                           ##STR778##              H   H   H   N(CH.sub.3).sub.2             n-C3 H.sub.7                                                                                ##STR779##              H   H   H    N(CH.sub.3).sub.2            n-C.sub. 3 H.sub.7                                                                          ##STR780##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             n-C4 H.sub.9                                                                           C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR781##     H   H   H   N(CH.sub. 3).sub.2            n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR782##     H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR783##     H   H   H   (N(CH.sub.3).sub.2                    ##STR784##                                                             n-C.sub.4 H.sub.9                                                                       ##STR785##                  H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                       ##STR786##                  H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                           ##STR787##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                           ##STR788##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                           ##STR789##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                           ##STR790##              H   H   H   N(CH.sub.3).sub.2             n-C.sub.4 H.sub.9                                                                           ##STR791##              H   H   H   N(CH.sub.3).sub.2             CH.sub.3                                                                               CH.sub.3     CH.sub.3        OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               CH.sub.3     C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H            CH.sub.2COOH    OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H                                                                                            ##STR792##     OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H                                                                                            ##STR793##     OH    CH.sub.2                                                                             H                             CH.sub. 3                                                                              H            CH.sub.2CH.sub.2COOH                                                                           OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH    CH.sub.2                                                                             H                             CH.sub.3                                                                               H                                                                                            ##STR794##     OH    CH.sub.2                                                                             H                                     ##STR795##                                                             CH.sub.3                                                                                ##STR796##                  OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                ##STR797##                  OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                    ##STR798##              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                    ##STR799##              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                    ##STR800##              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                    ##STR801##              OH    CH.sub.2                                                                             H                             CH.sub.3                                                                                    ##STR802##              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        CH.sub.3     CH.sub.3        OH    CH.sub.2                                                                             H                             C.sub. 2 H.sub.5                                                                       CH.sub.3     C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOH    OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR803##     OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H                                                                                            ##STR804##     OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2COOH                                                                           OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                        H            CH.sub.2CH.sub.2 COOC.sub.2 H.sub.5                                                            OH    CH.sub.2                                                                             H                             C.sub. 2 H.sub.5                                                                       H                                                                                            ##STR805##     OH    CH.sub.2                                                                             H                                     ##STR806##                                                             C.sub.2 H.sub.5                                                                         ##STR807##          OH            CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                         ##STR808##          OH            CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                             ##STR809##              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                             ##STR810##              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                             ##STR811##              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                             ##STR812##              OH    CH.sub.2                                                                             H                             C.sub.2 H.sub.5                                                                             ##STR813##              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     CH.sub.3        OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      CH.sub.3     C.sub.2 H.sub.7 OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      C.sub.2 H.sub. 5                                                                            C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2 COOH   OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR814##     OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR815##     OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      h            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                      H                                                                                            ##STR816##     OH    CH.sub.2                                                                             H                                     ##STR817##                                                             n-C.sub.3 H.sub.7                                                                       ##STR818##                  OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                       ##STR819##                  OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                           ##STR820##              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                           ##STR821##              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                           ##STR822##              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                           ##STR823##              OH    CH.sub.2                                                                             H                             n-C.sub.3 H.sub.7                                                                           ##STR824##              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     CH.sub.3        OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      CH.sub.3     C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      C.sub.2 H.sub.5                                                                             C.sub.2 H.sub.5 OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.3 H.sub.7                                                                           n-C.sub.3 H.sub.7                                                                              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      n-C.sub.4 H.sub.9                                                                           n-C.sub.4 H.sub.9                                                                              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOH    OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2COOC.sub.2 H.sub.5                                                                     OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR825##     OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR826##     OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOH                                                                           OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H            CH.sub.2CH.sub.2COOC.sub.2 H.sub.5                                                             OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                      H                                                                                            ##STR827##     OH    CH.sub.2                                                                             H                                     ##STR828##                                                             n-C.sub.4 H.sub.9                                                                       ##STR829##                  OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                       ##STR830##                  OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                           ##STR831##              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                           ##STR832##              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                           ##STR833##              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                           ##STR834##              OH    CH.sub.2                                                                             H                             n-C.sub.4 H.sub.9                                                                           ##STR835##              OH    CH.sub.2                                                                             H                             __________________________________________________________________________

The following Examples illustrate the invention.

EXAMPLE 1 N-(1,1-Diethoxy-2-pyrrolidinoethyl)-tetracycline

2.22 g of tetracycline base were dissolved in a mixture of 2.4 g of glyoxal-diethyl-monoacetal, 0.33 g of pyrrolidine and 10 ml of anhydrous methylene chloride and stirred at room temperature for 3 hours under an atmosphere of nitrogen. The solution was concentrated on a rotary evaporator to one third of its original volume. By pouring the solution into 50 ml of ether, the N-(1,1-diethoxy-2-pyrrolidinoethyl)-tetracycline was obtained in a well filtrable form. Yield: 2.0 g; M.p.: 117° C.

EXAMPLE 2 N-(1,1-Diethoxy-2-pyrrolidinoethyl)-tetracycline

A solution of 2.22 g of tetracycline base in 10 ml of methylene chloride was combined with 1,1-diethoxy-2,2-dipyrrolidinylethane prepared by the reaction of 1.32 g of glyoxal-diethyl-monoacetal and 1.42 g of pyrrolidine and the whole was stirred for 3 hours at room temperature under an atmosphere of nitrogen. The solution was concentrated and the product was precipitated with ether. M.p.: 117° C.

EXAMPLE 3 N-(1,1-Diethoxy-2-pyrrolidinoethyl)-tetracycline hydrochloride

2.4 g of tetracycline hydrochloride in 50 ml of isopropanol were combined with a mixture of 0.33 g of pyrrolidine and 2.4 g of glyoxal-diethyl-monoacetal and the whole was stirred for 5 hours at room temperature. The solvent was removed as far as possible under reduced pressure. Upon addition of ether, the N-(1,1-diethoxy-2-pyrrolidinoethyl)-tetracycline hydrochloride was obtained in solid form.

In the same manner as described in Example 1, there were obtained the compounds specified in Examples 4 to 20. The melting points indicated for them are decomposition points.

EXAMPLE 4 N-(1,1-Diethoxy-2-N-methylpiperazinoethyl)-tetracycline

M.p. 112° C.

EXAMPLE 5 N-(1,1-Diethoxy-2-diethylaminoethyl)-tetracycline

M.p. 92° to 98° C.

EXAMPLE 6 N-(1,1-Diethoxy-2-dimethylaminoethyl)-tetracycline

M.p. 111° to 116° C.

EXAMPLE 7 N-(1,1-Diethoxy-2-morpholinoethyl)-tetracycline

M.p. 106° C.

EXAMPLE 8 N-(1,1-Diethoxy-2-piperidinoethyl)-tetracycline

M.p. 95° to 105° C.

EXAMPLE 9 N-(1,1-Diethoxy-2-dimethylaminoisopropylaminoethyl)-tetracycline

M.p. 123° C.

EXAMPLE 10 N-(1,1-Diethoxy-2-n-propylaminoethyl)-tetracycline

M.p. 142° C.

EXAMPLE 11 N-(1,1-Diethoxy-2-n-butylaminoethyl)-tetracycline

M.p. 101° to 114° C.

EXAMPLE 12 N-(1,1-Dimethoxy-2-piperidinoethyl)-tetracycline

M.p. 140° C.

EXAMPLE 13 N-(1,1-Dimethoxy-2-dimethylaminoethyl)-tetracycline

M.p. 141° C.

EXAMPLE 14 N-(1,1-Dimethoxy-2-diethylaminoethyl)-tetracycline

M.p. 137° C.

EXAMPLE 15 N-(1,1-Dimethoxy-2-N-methylpiperazinoethyl)-tetracycline

M.p. 146° C.

EXAMPLE 16 N-(1,1-Dimethoxymorpholinoethyl)-tetracycline

M.p. 140° C.

EXAMPLE 17 N-(1,1-Dimethoxy-2-dimethylaminoisopropylaminoethyl)-tetracycline

M.p. 113° C.

EXAMPLE 18 N-(1,1-Dimethoxy-2-hydroxyethylaminoethyl)-tetracycline

M.p. 102° C.

EXAMPLE 19 N-(1,1-Dimethoxy-2-n-butylaminoethyl)-tetracycline

M.p. 113° C.

EXAMPLE 20 N-(1,1-Dimethoxy-2-pyrrolidinoethyl)-desmethyl-chlorotetracycline EXAMPLE 21 N-(1,1-Diethoxy-2-piperidinoethyl)-tetracycline citrate

2.22 g of tetracycline base were dissolved in a mixture of 2.4 g of glyoxal-diethylmonoacetal, 0.4 g of piperidine and 10 ml of anhydrous methylene chloride and the whole was stirred for 3 hours at room temperature under an atmosphere of nitrogen. A solution of 0.96 g of citric acid in 3 ml of ethanol was added, the mixture was concentrated under reduced pressure and the N-(1,1-diethoxy-2-piperidinoethyl)-tetracycline was precipitated by the addition of ether.

EXAMPLE 22 N-(1,1-Dimethoxy-2-morphonlinoethyl)-oxytetracycline

2.3 g of oxytetracycline base were introduced into a solution of 0.48 g of morpholine and 2.2 g of glyoxal-dimethyl-monoacetal in 10 ml of dimethylformamide. After having stirred for 3 hours under an atmosphere of nitrogen, the solution was concentrated under reduced pressure and the product was precipitated by the addition of 50 ml of ether.

Yield: 1.5 g; M.p. 110° C.

The compounds specified in the Examples 23 to 33 were prepared in a manner analogous to that described in Example 22.

EXAMPLE 23 N-(1,1-Dimethoxy-2-pyrrolidinoethyl)-oxytetracycline

M.p. 115° C.

EXAMPLE 24 N-(1,1-Dimethoxy-2-piperidinoethyl)-oxytetracycline EXAMPLE 25 N-(1,1-Dimethoxy-2-N-methylpiperazinoethyl)-oxytetracycline

M.p. 119° C.

EXAMPLE 26 N-(1,1-Dimethoxy-2-N-diethylaminoethyl)-oxytetracycline

M.p. 101° C.

EXAMPLE 27 N-(1,1-Dimethoxy-2-N-dimethylaminoethyl)-oxytetracycline

M.p. 116° C.

EXAMPLE 28 N-(1,1-Diethoxy-2-pyrrolidinoethyl)-oxytetracycline

M.p. from 104° to 109° C.

EXAMPLE 29 N-(1,1-Diethoxy-2-diethylaminoethyl)-oxytetracycline

M.p. from 86° to 102° C.

EXAMPLE 30 N-(1,1-Diethoxy-2-dimethylaminoethyl)-oxytetracycline

M.p. from 86° to 105° C.

EXAMPLE 31 N-(1,1-Diethoxy-2-morpholinoethyl)-oxytetracycline

M.p. 85° to 105° C.

EXAMPLE 32 N-(1,1-Diethoxy-2-piperidinoethyl)-oxytetracycline

M.p. from 99° to 109° C.

EXAMPLE 33 N-(1,1-Diethoxy-2-N-methylpiperazinoethyl)-oxytetracycline

M.p. from 103° to 117° C. 

We claim:
 1. A tetracycline of the formula ##SPC5##and physiologically tolerated salts thereof, wherein R¹ and R² are the same or different and are alkyl having 1 to 5 carbon atoms; R⁵ and R⁶, taken alone, are the same or different and are hydrogen or hydroxy; R⁷, taken alone, is hydrogen or methyl; or R⁶ and R⁷ taken together are methylene; R⁸ is hydrogen, chlorine, bromine or di-lower alkyl amino having 1 to 4 carbon atoms; R³, taken alone, is alkyl having 1 to 4 carbon atoms having at least one 5- or 6-membered heterocyclic substituent wherein the hetero atom is at least one member selected from the group consisting of oxygen and nitrogen; R⁴, taken alone, is hydrogen, alkyl having 1 to 6 carbon atoms, or alkyl having 1 to 6 carbon atoms having at lesst one substituent selected from the group consisting of hydroxy, di-lower alkyl amino, di-lower alkyl carbamoyl, lower alkoxy carbonyl, phenyl, a 5- or 6-membered heterocyclic substituent wherein the hetero atom is at least one member selected from the group consisting of oxygen and nitrogen, cycloalkyl having 5 to 7 carbon atoms, carboxy, and carboxy and amino; and R³ and R⁴, taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered nitrogen heterocycle which may be interrupted by a further nitrogen or oxygen atom and which may be substituted by lower alkyl, hydroxy lower alkyl, carboxy lower alkyl, hydroxy, or carbonyl.
 2. A compound as in claim 1 which is N-(1,1-diethoxy-2-pyrrolidino-ethyl) tetracycline.
 3. A method for making a compound as in claim 1 which comprises reacting a tetracycline of the formula ##SPC6##with an aldehyde of the formula ##STR836## and an amine of the formula ##STR837## wherein R¹ - R⁸ have the same meanings as in claim
 1. 4. A tetracycline of the formula ##SPC7##and physiologically tolerated salts thereof, wherein R¹ and R², taken alone, are the same or different and are alkyl having 1 to 5 carbon atoms; R¹ and R², taken together, are ethylene or propylene; R³ and R⁴, taken alone, are the same or different, are hydrogen, straight-chain or branched alkyl having 1 to 6 carbon atoms, straight-chain or branched alkyl having 1 to 6 carbon atoms which is substituted by at least one member selected from the group consisting of hydroxy, di-lower alkyl-amino, di-lower alkyl-carbamoyl, lower alkoxy-carbonyl, phenyl, a 5- or 6-membered heterocyclic substituent wherein the hetero atom is at least one member selected from the group consisting of oxygen and nitrogen, cycloalkyl having 5 to 7 carbon atoms, carboxy, and carboxy together with amino; R³ and R⁴, taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocycle which may be interrupted by a further nitrogen or oxygen atom and which may be substituted by lower alkyl, hydroxy lower alkyl, carboxy lower alkyl, hydroxy, or carbonyl; R⁵ and R⁶ are the same or different and are hydrogen or hydroxy; R⁷ is hydrogen or methyl; R⁶ and R⁷, taken together, are methylene; and R⁸ is hydrogen, chlorine, bromine, or di-alkyl amino in which the alkyl groups each have 1 to 4 carbon atoms.
 5. The method of making a tetracycline as in claim 4 which comprises reacting a tetracycline of the formula ##SPC8##with an aldehyde of the formula ##STR838## and an amine of the formula ##STR839## wherein R¹ - R⁸ have their earlier meanings.
 6. The method as in claim 5 wherein the tetracycline product is subsequently acidified to form a physiologically tolerated salt thereof.
 7. The method as in claim 5 wherein the tetracycline reagent or said amine are reacted in the form of a salt thereof.
 8. The method as in claim 5 which is carried out in two stages as a transaminoalkylation.
 9. An antibacterially-active pharmaceutical composition comprising a tetracycline or salt thereof as in claim 4 in combination with a pharmaceutical excipient.
 10. The method of making a pharmaceutical composition which comprises bringing a tetracycline or salt thereof as in claim 4, alone or in combination with a pharmaceutical excipient, into a therapeutically-administrable form. 